associations between tamoxifen, estrogens, and fsh serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer它莫西芬之间的关联、雌激素和血清fsh水平稳定状态期间它莫西芬治疗乳腺癌的绝经后妇女.pdfVIP
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associations between tamoxifen, estrogens, and fsh serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer它莫西芬之间的关联、雌激素和血清fsh水平稳定状态期间它莫西芬治疗乳腺癌的绝经后妇女
Gjerde et al. BMC Cancer 2010, 10:313
/1471-2407/10/313
R E S E A R C H A R T I C L E Open Access
Research article
Associations between tamoxifen, estrogens, and
FSH serum levels during steady state tamoxifen
treatment of postmenopausal women with breast
cancer
1,2 3,4,5 6,7 3 8,9 1,2
Jennifer Gjerde , Jürgen Geisler , Steinar Lundgren , Dagfinn Ekse , Jan Erik Varhaug , Gunnar Mellgren ,
Vidar M Steen 10,11 1,2
and Ernst A Lien*
Abstract
Background: The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective
estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-
hydroxy-N-demethyltamoxifen (4OHNDtam, endoxifen). Inter-individual variations of the activity of these enzymes due
to polymorphisms may be predictors of outcome of breast cancer patients during tamoxifen treatment. Since
tamoxifen and estrogens are both partly metabolized by these enzymes we hypothesize that a correlation between
serum tamoxifen and estrogen levels exists, which in turn may interact with tamoxifen on treatment outcome. Here we
examined relationships between the serum levels of tamoxifen, estrogens, follicle-stimulati ng hormone (FSH), and also
determined the genotypes of CYP2C19, 2D6, 3A5, and SULT1A1 in 90 postmenopausal breast cancer patients.
Methods: Tamoxifen and its metabolites were measured by liquid chromatography-tandem mass spectrometry.
Estrogen and FSH levels were determined using a sensitive radio- and chemiluminescent immunoassay, respectively.
Results: We observed significant correlations between the serum concentrations of tamoxifen, N-
dedimethyltamoxife
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