associations of fetuin-a levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy协会fetuin-a水平与2型糖尿病血管疾病患者早期糖尿病肾病.pdfVIP

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associations of fetuin-a levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy协会fetuin-a水平与2型糖尿病血管疾病患者早期糖尿病肾病.pdf

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associations of fetuin-a levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy协会fetuin-a水平与2型糖尿病血管疾病患者早期糖尿病肾病

Roos et al. Cardiovascular Diabetology 2010, 9:48 CARDIO /content/9/1/48 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Associations of Fetuin-A levels with vascular disease in type 2 diabetes patients with early diabetic nephropathy 1* 3 1 2 1 1 Marcel Roos , Dimitrios Oikonomou , Maximilian von Eynatten , Peter B Luppa , Uwe Heemann , Jens Lutz , Marcus Baumann1 3 3 3 , Peter P Nawroth , Angelika Bierhaus , Per M Humpert Abstract Background: Ambigous results exist on fetuin-A as marker for vascular disease in type 2 diabetes. This study aims to define the role of fetuin-A as marker for micro- and macrovascular disease in a high risk population of patients with type 2 diabetes mellitus and early diabetic nephropathy. Methods: Fetuin-A serum levels were assessed by ELISA in a cross-sectional setting in 153 patients with type 2 diabetes. Associations of fetuin-A with metabolic, inflammatory and vascular markers were studied. Atherosclerotic burden was assessed by ankle-brachial-index (ABI) as well as detection of common carotid artery intima-media thickness (IMT). Results: Levels of fetuin-A were lower in male than in female patients (0.49 ± 0.15 vs. 0.56 ± 0.20 g/L, p = 0.02). In addition, there was an inverse correlation with age (r = -0.20, P = 0.01). Bivariate correlations adjusted for age and gender revealed no significant cor