原创力文档associations of airway inflammation and responsiveness markers in non asthmatic subjects at start of apprenticeship协会非哮喘气道炎症和响应性标记的对象在学徒期的开始.pdfVIP
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associations of airway inflammation and responsiveness markers in non asthmatic subjects at start of apprenticeship协会非哮喘气道炎症和响应性标记的对象在学徒期的开始
Demange et al. BMC Pulmonary Medicine 2010, 10:37
/1471-2466/10/37
R E S E A R C H A R T I C L E Open Access
Research article
Associations of airway inflammation and
responsiveness markers in non asthmatic subjects
at start of apprenticeship
1 1 2,3,4 2,5 2,6 7
Valérie Demange* , Pascal Wild , Denis Zmirou-Navier , Paul Tossa , Abraham Bohadana , Annick Barbaud and
Christophe Paris2,3
Abstract
Background: Bronchial Hyperresponsiveness (BHR) is considered a hallmark of asthma. Other methods are helpful in
epidemiological respiratory health studies including Fractional Exhaled Nitric Oxide (FENO) and Eosinophils Percentage
(EP) in nasal lavage fluid measuring markers for airway inflammation along with the Forced Oscillatory Technique
measuring Airway resistance (AR). Can their outcomes discriminate profiles of respiratory health in healthy subjects
starting apprenticeship in occupations with a risk of asthma?
Methods: Rhinoconjunctivitis, asthma-like symptoms, FEV1 and AR post-Methacholine Bronchial Challenge (MBC) test
results, FENO measurements and EP were all investigated in apprentice bakers, pastry-makers and hairdressers not
suffering from asthma. Multiple Correspondence Analysis (MCA) was simultaneously conducted in relation to these
groups and this generated a synthetic partition (EI). Associations between groups of subjects based on BHR and EI
respectively, as well as risk factors, symptoms and investigations were also assessed.
Results: Among the 441 apprentice subjects, 45 (10%) declared rhinoconjunctivitis-like symptoms, 18 (4%) declared
asthma-like symptoms and 26 (6%) suffered from BHR. The mean increase in AR post-MBC test was 21% (sd = 20.8%).
The median of FENO va
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