association of mesenchymal cells and immunoglobulins with differentiating epithelial cells协会与分化上皮细胞间充质细胞和免疫球蛋白.pdfVIP

BMC Developmental Biology (2001) 1:11 /1471-213X/1/11 BMC Developmental Biology (2001) 1:11 Research article Association of mesenchymal cells and immunoglobulins with differentiating epithelial cells 1 1 1 Antonin Bukovsky* , Michael R Caudle , Jeffrey A Keenan , 1 2 1 Nirmala B Upadhyaya , Stuart E Van Meter , Jay Wimalasena and Robert F Elder1 Address: 1Laboratory for Development, Differentiation and Cancer, Department of Obstetrics and Gynecology, and and 2Deepartment of Pathology, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920, USA E-mail: Antonin Bukovsky* - buko@; Michael R Caudle - mcaudle@; Jeffrey A Keenan - jkeenan@; Nirmala B Upadhyaya - nbupadha@; Stuart E Van Meter - svanmete@; Jay Wimalasena - jwimalas@; Robert F Elder - relder@ *Corresponding authors Published: 22 June 2001 Received: 4 April 2001 Accepted: 22 June 2001 BMC Developmental Biology 2001, 1:11 This article is available from: /1471-213X/1/11 (c) 2001 Bukovsky et al, licensee BioMed Central Ltd. Abstract Background: Mesenchymal-epithelial interactions play an important role in the physiology and pathology of epithelial tissues. Mesenchymal cells either associate with epithelium basement membrane [pericytes and perivascular monocyte-derived cells (MDC)] or reside within epithelium (MDC and T cells). Although intraepithelial mesenchymal cells were suggested to contribute to the epithelium physiology, their