associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio a cross-sectional study协会的年龄与血清胰岛素,胰岛素原,proinsulin-to-insulin比率横断面研究.pdfVIP

Bryhni et al. BMC Endocrine Disorders 2010, 10:21 /1472-6823/10/21 RESEARCH ARTICLE Open Access Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross- sectional study 1,2* 3 2,4 Bente Bryhni , Egil Arnesen , Trond G Jenssen Abstract Background: Insulin responses and insulin levels seem to decline with age. However, the question of beta cell impairment attributable to ageing has been sparsely addressed in population-based studies. Non-fasting insulin levels are determined by the ambient degree of insulin resistance together with the capacity of beta cells to compensate by insulin secretion to prevent hyperglycaemia. A raised proinsulin-to-insulin ratio (proinsulin/insulin) due to impaired processing of proinsulin is an early marker of beta cell dysfunction. We hypothesised that in a general population, signs of beta cell failure with advancing age manifest not only by decreases in random insulin, but also with a corresponding increase in its precursor proinsulin. Methods: In the Tromsø Study 1994-95 we measured insulin and proinsulin concentrations in random blood samples from 6212 persons without self-reported diabetes mellitus and plotted the levels as percentiles according to age. In regression analyses we assessed the relationships between age and insulin, proinsulin, and proinsulin/ insulin, while adjusting for the concomitant measurements of glucose and other metabolic variables, and the time since the last meal. Results: Median insulin concentrations declined significantly with advancing age group in men, but not in women. Proinsulin levels and proinsulin/insulin increased across age groups in both genders. After adjustment, greater age was associated with lower log10(insulin) and higher log10(proinsuli