osteoclasts; culprits in inflammatory osteolysis破骨细胞;.pdfVIP

Available online /content/8/1/201 Review Osteoclasts; culprits in inflammatory osteolysis Steven L Teitelbaum Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA Corresponding author: Steven L Teitelbaum, teitelbs@ Published: 29 November 2005 Arthritis Research Therapy 2006, 8:201 (doi:10.1186/ar1857) This article is online at /content/8/1/201 © 2005 BioMed Central Ltd Abstract characterized by enhanced bone mass caused by a failure of osteoclast recruitment or function. The fact that an Periarticular osteolysis, a crippling complication of rheumatoid arthritis, is the product of enhanced osteoclast recruitment and osteopetrotic child was cured by marrow transplantation in activation. The osteoclast, which is a member of the monocyte/ the early 1980s established that the human osteoclast is of macrophage family, is the exclusive bone resorptive cell, and its hematopoietic origin [6]. Subsequent studies document that differentiation and activation are under the aegis of a variety of the resorptive cell is a member of the monocyte/macrophage cytokines. Receptor activator of NF-κB ligand (RANKL) and family [7] and provide the tools for generating the cell in macrophage colony-stimulating factor are the essential osteo- clastogenic cytokines and are increased in inflamma