p16 as a diagnostic marker of cervical neoplasia a tissue microarray study of 796 archival specimensp16宫颈肿瘤的诊断标记796档案的组织微阵列研究标本.pdfVIP

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p16 as a diagnostic marker of cervical neoplasia a tissue microarray study of 796 archival specimensp16宫颈肿瘤的诊断标记796档案的组织微阵列研究标本.pdf

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p16 as a diagnostic marker of cervical neoplasia a tissue microarray study of 796 archival specimensp16宫颈肿瘤的诊断标记796档案的组织微阵列研究标本

Diagnostic Pathology BioMed Central Research Open Access p16 as a diagnostic marker of cervical neoplasia: a tissue microarray study of 796 archival specimens 1 2 1 Iana Lesnikova* , Marianne Lidang , Stephen Hamilton-Dutoit and Jørn Koch1 Address: 1Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark and 2Institute of Pathology, Herlev Hospital, Herlev, Denmark Email: Iana Lesnikova* - janalni@yahoo.dk; Marianne Lidang - marlid01@heh.regionh.dk; Stephen Hamilton-Dutoit - stephami@rm.dk; Jørn Koch - joerkoch@rm.dk * Corresponding author Published: 9 July 2009 Received: 7 May 2009 Accepted: 9 July 2009 Diagnostic Pathology 2009, 4:22 doi:10.1186/1746-1596-4-22 This article is available from: /content/4/1/22 © 2009 Lesnikova et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: To evaluate the usefulness of this biomarker in the diagnosis of cases of cervical neoplasia we studied the immunohistochemical expression of p16INK4a in a large series of archival cervical biopsies arranged into tissue microarray format. Methods: TMAs were constructed with tissue cores from archival formalin fixed, paraffin-