原创力文档p300 amplitude is insensitive to working memory load in schizophreniap300波幅对工作记忆负载在精神分裂症.pdfVIP
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p300 amplitude is insensitive to working memory load in schizophreniap300波幅对工作记忆负载在精神分裂症
Gaspar et al. BMC Psychiatry 2011, 11:29
/1471-244X/11/29
RESEARCH ARTICLE Open Access
P300 amplitude is insensitive to working memory
load in schizophrenia
1,2* 3,4,5 5 5 5 6
Pablo A Gaspar , Sergio Ruiz , Francisco Zamorano , Marcela Altayó , Carolina Pérez , Conrado A Bosman ,
Francisco Aboitiz5
Abstract
Background: Working memory (WM) tasks usually elicit a P300 ERP component, whose amplitude decreases with
increasing WM load. So far, this effect has not been studied in schizophrenics (SZs), a group that is considered to
have an aberrant brain connectivity and impairments in WM capacity. The aim of this study was to determine the
dependency of the P300 component on WM load in a sample of SZ subjects.
Methods: We recorded 26 subjects (13 SZ patients and their matched controls) with an 80-channel
electroencephalogram. Subjects performed an N-back task, a WM paradigm that manipulates the number of items
to be stored in memory.
Results: In healthy subjects, P300 amplitude was highest in the low WM load condition, and lowest in both the
attentional control condition and the high WM load condition. In contrast, SZs evidenced low P300 amplitude in
all conditions. A significant between group difference in P300 amplitude was evidenced only at the low WM load
condition (1 -back), being smaller in SZs.
Conclusions: SZ subjects display a lower than normal P300 amplitude, which does not vary as a function of
memory load. These results are consistent with a general impairment in WM capacity in these patients.
Background have been consistently reported in first episode patients
Working memory (WM) refers to a set of cognitive pro-
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