partial protection against collagen antibody-induced arthritis in parp-1 deficient mice部分保护胶原蛋白antibody-induced关节炎parp-1不足的老鼠.pdf

Available online /content/8/1/R14 Vol 8 No 1 Open Access Research article Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice 1 1 1 2 3 Samuel García , Ana Bodaño , Antonio González , Jerónimo Forteza , Juan J Gómez-Reino and Carmen Conde1 1Research Laboratory, Hospital Clínico Universitario, Choupana s/n, 15706-Santiago de Compostela, Spain 2Department of Pathology, Hospital Clínico Universitario, Choupana s/n, 15706-Santiago de Compostela, Spain 3Rheumatology Unit, Hospital Clínico Universitario and Department of Medicine, Universidad de Santiago, San Francisco s/n, 15700-Santiago de Compostela, Spain Corresponding author: Carmen Conde, Carmen.Conde.Muro@sergas.es Received: 18 Feb 2005 Revisions requested: 16 Mar 2005 Revisions received: 8 Nov 2005 Accepted: 9 Nov 2005 Published: 6 Dec 2005 Arthritis Research Therapy 2006, 8:R14 (doi:10.1186/ar1865) This article is online at: /content/8/1/R14 © 2005 García et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear DNA- Decreased clinical scores were accompanied by partial binding protein that participates in the regulation of DNA repair reduction of histopathological findings. Interestingly, and maintenance of genomic integrity. In addition, P