pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder模式语言流畅的神经反应显示了精神分裂症和双相情感障碍的诊断特异性.pdfVIP

Costafreda et al. BMC Psychiatry 2011, 11:18 /1471-244X/11/18 RESEARCH ARTICLE Open Access Pattern of neural responses to verbal fluency shows diagnostic specificity for schizophrenia and bipolar disorder * Sergi G Costafreda , Cynthia HY Fu, Marco Picchioni, Timothea Toulopoulou, Colm McDonald, Eugenia Kravariti, Muriel Walshe, Diana Prata, Robin M Murray, Philip K McGuire Abstract Background: Impairments in executive function and language processing are characteristic of both schizophrenia and bipolar disorder. Their functional neuroanatomy demonstrate features that are shared as well as specific to each disorder. Determining the distinct pattern of neural responses in schizophrenia and bipolar disorder may provide biomarkers for their diagnoses. Methods: 104 participants underwent functional magnetic resonance imaging (fMRI) scans while performing a phonological verbal fluency task. Subjects were 32 patients with schizophrenia in remission, 32 patients with bipolar disorder in an euthymic state, and 40 healthy volunteers. Neural responses to verbal fluency were examined in each group, and the diagnostic potential of the pattern of the neural responses was assessed with machine learning analysis. Results: During the verbal fluency task, both patient groups showed increased activation in the anterior cingulate, left dorsolateral prefrontal cortex and right putamen as compared to healthy controls, as well as reduced deactivation of precuneus and posterior cingulate. The magnitude of activation was greatest in patients with schizophrenia, followed by patients with bipolar disorder and then healthy individuals. Additional recruitment in the right inferior frontal and right dorsolateral prefrontal cortices was observed in schizophrenia relative to both bipolar disorder and healthy subjects