原创力文档overexpression of c-erbb2 is a negative prognostic factor in anaplastic astrocytomasc-erbb2超表达是消极的间变性星形细胞瘤的预后因素.pdfVIP
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overexpression of c-erbb2 is a negative prognostic factor in anaplastic astrocytomasc-erbb2超表达是消极的间变性星形细胞瘤的预后因素
Gulati et al. Diagnostic Pathology 2010, 5:18
/content/5/1/18
RESEARCH Open Access
Overexpression of c-erbB2 is a negative
prognostic factor in anaplastic astrocytomas
1,2* 2 2 4 5 2,3
Sasha Gulati , Borgny Ytterhus , Unn S Granli , Michel Gulati , Stian Lydersen , Sverre H Torp
Abstract
The epidermal growth factor receptor (EGFR) family, consisting of four tyrosine kinase receptors, c-erbB1-4, seems
to be influential in gliomagenesis. The aim of this study was to investigate EGFR gene amplification and expression
of c-erbB1-4 receptor proteins in human anaplastic astrocytomas. Formalin-fixed and paraffin-embedded sections
from 31 cases were investigated by standard immunohistochemical procedures for expression of c-erbB1-4 receptor
proteins using commercial antibodies. EGFR gene amplification was studied by fluorescence in situ hybridization
using paraffin-embedded tissues. Two monoclonal antibodies, NCL-EGFR-384 and NCL-EGFR, were used for EGFR
detection and they displayed positive immunoreactivity in 97% and 71%, respectively. For c-erbB2 detection three
monoclonal antibodies, CB11, 3B5, and 5A2, were applied and they displayed positive immunoreactivity in 45%,
100%, and 52%, respectively. Positive immunostaining for c-erbB3 and c-erbB4 was encountered in 97% and 74%,
respectively. The EGFR gene was amplified in 9 out of 31 tumors (29%). After adjusting for age, Karnofsky perfor-
mance status, and extent of surgical resection, Cox multiple regression analysis with overall survival as the depen-
dent variable revealed that c-erbB2 overexpression detected by the monoclonal antibody clone CB11 was a
statistically significant poor prognostic factor (P = 0.004). This study shows the convenience and feas
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