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overexpression of ribosome binding protein 1 (rrbp1) in breast cancer过度的核糖体结合蛋白1(rrbp1)在乳腺癌.pdf

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overexpression of ribosome binding protein 1 (rrbp1) in breast cancer过度的核糖体结合蛋白1(rrbp1)在乳腺癌

Telikicherla et al. Clinical Proteomics 2012, 9:7 /content/9/1/7 CLINICAL PROTEOMICS RESEARCH Open Access Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer 1,2 1 1 2 1,3 Deepthi Telikicherla , Arivusudar Marimuthu , Manoj Kumar Kashyap , Y L Ramachandra , Sujatha Mohan , 4 1,5,6* 7,8,9,10,11* Juan Carlos Roa , Jagadeesha Maharudraiah and Akhilesh Pandey * Correspondence: jagadeesha@ Abstract ; pandey@jhmi. edu 1Institute of Bioinformatics, The molecular events that lead to malignant transformation and subsequent International Tech Park, Bangalore metastasis of breast carcinoma include alterations in the cells at genome, 560 066, India transcriptome and proteome levels. In this study, we used publicly available gene 5Department of Pathology and Laboratory Medicine, Icon Hospitals, expression databases to identify those candidate genes which are upregulated at the Bangalore 560027, India mRNA level in breast cancers but have not been systematically validated at the Full list of author information is protein level. Based on an extensive literature search, we identified ribosome binding available at the end of the article protein 1 (RRBP1) as a candidate that is upregulated at the mRNA level in five different studies but its protein expre