pharmacological evaluation of liuwei zhuanggu granules in rats老鼠体内药理评价刘为zhuanggu颗粒.pdfVIP

Molecules 2012, 17, 8001-8009; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Pharmacological Evaluation of LiuWei Zhuanggu Granules in Rats Haiming Zhu, Liang Ding, Haijun Xiao, Weifeng Ni, Feng Xue and Zhiming He * Department of Orthopaedic Surgery, Shanghai Fengxian Central Hospital, No. 9588, NanFeng Road, Fengxian District, Shanghai 201400, China; E-Mails: haimzhu@126.com (H.Z.); ldingphg@126.com (L.D.); hjxiaojkt@126.com (H.X.); wfnifgh@126.com (W.N.); fxuefgts@126.com (F.X.) * Author to whom correspondence should be addressed; E-Mail: zmhesf@126.com; Tel./Fax: +86-021-5742-4345. Received: 4 June 2012; in revised form: 20 June 2012 / Accepted: 20 June 2012 / Published: 3 July 2012 Abstract: Many commonly consumed foods, herbs and spices contain a complex array of naturally occurring bioactive molecules called phytochemicals, which may confer health benefits. In this study, the impact of LiuWei Zhuanggu Granules (LWZGG) on mineral metabolism in osteopenia development was evaluated. Results showed that serum estrogen, bone gla protein (BGP), and calcitonin (CT) levels, bone Ca, Zn and Cu levels, femur, lumbar vertebrae and trabecular bone density, tibia maximum stress and maximum bending strength were increased, and serum parathyroid hormone (PTH), serum and urine Ca, Zn and Cu levels were decreased in rat bone. It can be concluded that LWZGG is useful to improve bone quality in ovariectomized (OVX) rats. Keywo