phenol levels during intralesional curettage and local adjuvant treatment of benign and low-grade malignant bone tumours苯酚含量在intralesional刮除术和地方良性和低度恶性骨肿瘤的辅助治疗.pdfVIP

Verdegaal et al. Clinical Sarcoma Research 2012, 2:10 /content/2/1/10 CLINICAL SARCOMA RESEARCH RESEARCH Open Access Phenol levels during intralesional curettage and local adjuvant treatment of benign and low- grade malignant bone tumours 1* 2 3 1 Suzan HM Verdegaal , Jan den Hartigh , Pancras CW Hogendoorn , Hugo FG Brouwers and Antonie HM Taminiau1 Abstract Background: Phenol is widely used for years as local adjuvant treatment for bone tumours. Despite its use for a long time, no information is available about the local concentration of phenol that is achieved in an individual patient, and the most sufficient and safe procedure to wash out the phenol after using it as local adjuvant. Questions/purposes: 1. What is the initial local concentration of phenol in the tissue of the cavity wall after the application of phenol? 2. How quickly is phenol 85% diluted by washing the bone cavity with ethanol 96% solution? 3. Is the degree and speed of dilution influenced by the size of the cavity? 4. How many times should the cavity be rinsed to obtain sufficient elimination of phenol? Methods: A basic science study was performed at respectively 16 and 10 patients, treated by intralesional curettage and adjuvant therapy for low-grade central chondrosarcoma of bone. Test 1:in 16 patients ten samples were collected of the mixture of phenol and ethanol from the bone cavity. Test 2:in ten patients, two biopsy samples were taken from the cavity wall in the bone during surgery. Results: Phenol concentrations had wide variety in different patients, but all decreased by rinsing with ethanol. Conclusions: Ethanol 96% is effective to wash out local applicat