原创力文档predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets预测生物标志物发现通过临床试验的并行集成和功能基因组学数据集.pdfVIP
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predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets预测生物标志物发现通过临床试验的并行集成和功能基因组学数据集
Swanton et al. Genome Med 2010, 2:53
/content/2/8/53
CORRESPONDENCE Open Access
Predictive biomarker discovery through the
parallel integration of clinical trial and functional
genomics datasets
1,2*† 2† 1,3† 4† 1 1,2
Charles Swanton , James M Larkin , Marco Gerlinger , Aron C Eklund , Michael Howell , Gordon Stamp ,
Julian Downward 1 2 5 6 6 6
, Martin Gore , P Andrew Futreal , Bernard Escudier , Fabrice Andre , Laurence Albiges ,
7 7 8 9 10 11
Benoit Beuselinck , Stephane Oudard , Jens Hoffmann , Balázs Gyorffy , Chris J Torrance , Karen A Boehme ,
Hansjuergen Volkmer11 12 12 4 4
, Luisella Toschi , Barbara Nicke , Marlene Beck , Zoltan Szallasi
Abstract
The European Union multi-disciplinary Personalised RNA interference to Enhance the Delivery of Individualised
Cytotoxic and Targeted therapeutics (PREDICT) consortium has recently initiated a framework to accelerate the
development of predictive biomarkers of individual patient response to anti-cancer agents. The consortium focuses
on the identification of reliable predictive biomarkers to approved agents with anti-angiogenic activity for which
no reliable predictive biomarkers exist: sunitinib, a multi-targeted tyrosine kinase inhibitor and everolimus, a mam-
malian target of rapamycin (mTOR) pathway inhibitor. Through the analysis of tumor
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