predictors of adherence to antiretroviral therapy among people living with hivaids in resource-limited setting of southwest ethiopia预测坚持抗逆转录病毒治疗的患者在资源有限的条件设置西南埃塞俄比亚.pdfVIP
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predictors of adherence to antiretroviral therapy among people living with hivaids in resource-limited setting of southwest ethiopia预测坚持抗逆转录病毒治疗的患者在资源有限的条件设置西南埃塞俄比亚
Tiyou et al. AIDS Research and Therapy 2010, 7:39
/content/7/1/39
RESEARCH Open Access
Predictors of adherence to antiretroviral therapy
among people living with HIV/AIDS in resource-
limited setting of southwest ethiopia
1 2 3 3*
Ayele Tiyou , Tefera Belachew , Fisehaye Alemseged , Sibhatu Biadgilign
Abstract
Background: Good adherence to antiretroviral therapy is necessary to achieve the best virological response, lower
the risk that drug resistance will develop, and reduce morbidity and mortality. Little is known about the rate and
predictors of adherence in Ethiopia. Therefore this study determines the magnitude and predictors of adherence to
antiretroviral therapy among people living with HIV/AIDS in Southwest Ethiopia.
Methods: A cross sectional study was carried out from January 1, 2009 to March 3, 2009 among 319 adult PLWHA
(≥ 18 years) attending ART clinic at Jimma university Specialized Hospital (JUSH). Multiple Logistic regression
models were constructed with adherence and independent variables to identify the predictors.
Results: About 303(95%) of the study subjects were adherent based on self report of missed doses (dose
adherence) in a one-week recall before the actual interview. The rate of self reported adherence in the study based
on the combined indicator of the dose, time and food adherence measurement was 72.4%. Patients who got
family support were 2 times [2.12(1.25-3.59)] more likely to adhere than those who didn’t get family support as an
independent predictor of overall adherence (dose, time and food). The reasons given for missing drugs were 9
(27.3%) running out of medication/drug, 7(21.2%) being away from home and 7(21.2%) being busy with other
things.
Conclusion: The adherence rate found in
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