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predictors of infusion reactions during infliximab treatment in patients with arthritis输液反应的预测在英夫利昔单抗治疗关节炎患者.pdf

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predictors of infusion reactions during infliximab treatment in patients with arthritis输液反应的预测在英夫利昔单抗治疗关节炎患者

Available online /content/8/4/R131 Vol 8 No 4 Open Access Research article Predictors of infusion reactions during infliximab treatment in patients with arthritis 1 1 2 1 1 Meliha C Kapetanovic , Lotta Larsson , Lennart Truedsson , Gunnar Sturfelt , Tore Saxne and Pierre Geborek1 1Department of Rheumatology, Lund University Hospital, Lund, Sweden 2Department of Clinical Microbiology and Immunology, Lund University Hospital, Lund, Sweden Corresponding author: Meliha C Kapetanovic, meliha.crnkic@med.lu.se Received: 27 Apr 2006 Revisions requested: 24 May 2006 Revisions received: 10 Jul 2006 Accepted: 26 Jul 2006 Published: 26 Jul 2006 Arthritis Research Therapy 2006, 8:R131 (doi:10.1186/ar2020) This article is online at: /content/8/4/R131 © 2006 Kapetanovic et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract In the present study we evaluated the impact of baseline patients with baseline ANA positivity alone was 2.1. Infliximab antinuclear antibody (ANA) status and use of methotrexate on without methotrexate and infliximab as monotherapy were development of infliximab-related infusion reactions in patients associated with ORs of 3.1 and 3.6, respectively. Combining with rheumatoid arthritis (RA) or spondylarthropathies (SpAs), infliximab without methotrexate and