predictors of interstitial lung disease in early systemic sclerosis a prospective longitudinal study of the genisos cohort间质性肺疾病的预测在早期系统性硬化症的前瞻性纵向研究genisos队列.pdfVIP

Assassi et al. Arthritis Research Therapy 2010, 12:R166 /content/12/5/R166 RESEARCH ARTICLE Open Access Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort 1,2* 1 2 3 4 5 Shervin Assassi , Roozbeh Sharif , Robert E Lasky , Terry A McNearney , Rosa M Estrada-Y-Martin , Hilda Draeger 1 6 1 1 1 , Deepthi K Nair , Marvin J Fritzler , John D Reveille , Frank C Arnett , Maureen D Mayes , the GENISOS Study Group Abstract Introduction: The objective of the present study was to examine the association of baseline demographic and clinical characteristics with sequentially obtained measurements of forced vital capacity (FVC), expressed as a percentage of the predicted value, and to identify predictors of the decline rate in FVC over time in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS). Methods: To date, 266 patients have been enrolled in GENISOS, a prospective, observational cohort of patients with early systemic sclerosis. In addition to pulmonary function tests (PFTs), clinical and laboratory data were obtained from each patient. We analyzed 926 FVC measurements utilizing generalized linear mixed models. The predictive significance of baseline variables for the decline rate in FVC was investigated by the interaction term between the variable and the follow-up time within the first 3 years after enrollment as well as throughout the entire follow-up time. Results: The cohort consisted of 125 white, 54 African American, and 77 Hispanic patients with average disease duration of 2.5 years at enro