predictive value of pathological and immunohistochemical parameters for axillary lymph node metastasis in breast carcinoma病理和免疫组织化学参数的预测价值在乳腺癌腋窝淋巴结转移.pdfVIP

Yenidunya et al. Diagnostic Pathology 2011, 6:18 /content/6/1/18 RESEARCH Open Access Predictive value of pathological and immunohistochemical parameters for axillary lymph node metastasis in breast carcinoma * Sibel Yenidunya , Reyhan Bayrak, Hacer Haltas Abstract Background/Objective: While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. Axillary lymph node metastasis (ALNM) is one of the most important prognostic determinants in breast carcinoma; however, the reasons why tumors vary in their capability to result in axillary metastasis remain unclear. Identifying breast carcinoma patients at risk for ALNM would improve treatment planning. This study aimed to identify the factors associated with ALNM in breast carcinoma, with particular emphasis on basal-like phenotype. Methods: Breast carcinoma patients (n = 210) who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy were included in this study. Pathological and immunohistochemical data including individual receptor/gene status was collected for analysis. The basal phenotype status was ascertained using the basal cytokeratin markers CK5, CK14, CK17 and EGFR. Results: ALNM was found in 55% (n = 116) of the patients. On univariate analysis, multicentric disease, large tumor size (2 cm), vascular and lymphatic invasion, epithelial hyperplasia, necrosis, in situ carcinoma and perineural invasion were associated with higher risk for ALNM, whereas CK5, CK14, EGFR positivity and basal-like tumor type were associated with lower risk. On multivariate analysis, CK5 positivity (OR 0.003, 95%CI 0.000-