prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort产前补充微量营养素在怀孕和产后抑郁症状群.pdfVIP

Leung et al. BMC Pregnancy and Childbirth 2013, 13:2 /1471-2393/13/2 RESEARCH ARTICLE Open Access Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort 1 1,2* 3 1,2 1,4 Brenda MY Leung , Bonnie J Kaplan , Catherine J Field , Suzanne Tough , Misha Eliasziw , 3 3 5 Mariel Fajer Gomez , Linda J McCargar , Lisa Gagnon and the APrON Study Team Abstract Background: Postpartum depression is a serious problem for women and their offspring. Micronutrient supplements are recommended for pregnant women because of their documented protective effects for the offspring, but their potential beneficial effects on maternal mental health are unknown. This study investigated the association between prenatal micronutrient supplementation and the risk for symptoms of postpartum depression in a longitudinal pregnancy cohort from the Alberta Pregnancy Outcomes and Nutrition (APrON) study. Methods: Participants came from a cohort of the first 600 APrON women. Supplemental nutrient intake and symptoms of depression (measured with the Edinburgh Postnatal Depression Scale (EPDS)) were collected at each trimester and 12 weeks postpartum. Results: Of the 475 participants who completed the EPDS at least twice in pregnancy and at 12 weeks postpartum, 416 (88%) scored 10 and 59 (12%) scored ≥10, where an EPDS ≥10 is considered to be “at least probable minor depression”. Mean nutrient intakes from supplements were higher in women with lower EPDS scores, particularly selenium (p = 0.0015) and omega-3s (p = 0.01). Bivariate analyses showed that several demographic and social/ lifestyle variables we