prevalence of birth defects and risk-factor analysis from a population-based survey in inner mongolia, china患病率以人群为基础的出生缺陷和危险因素分析调查内蒙古,中国.pdfVIP

Zhang et al. BMC Pediatrics 2012, 12:125 /1471-2431/12/125 RESEARCH ARTICLE Open Access Prevalence of birth defects and risk-factor analysis from a population-based survey in Inner Mongolia, China 1 1* 1 2 3 4 4 Xingguang Zhang , Su Li , Siqintuya Wu , Xiaojin Hao , Shuyi Guo , Kota Suzuki , Hiroshi Yokomichi and Zentaro Yamagata4 Abstract Background: Birth Defects are a series of diseases that seriously affect childrens health. Birth defects are generally caused by several interrelated factors. The aims of the article is to estimate the prevalence rate and types of birth defects in Inner Mongolia, China, to compare socio-demographic characteristics among the children with birth defects and to analyze the association between risk factors and birth defects. Methods: Data used in this study were obtained through baseline survey of Inner Mongolia Birth Defects Program, a population-based survey conducted from 2005 to 2008. The survey used cluster sampling method in all 12 administrative districts of Inner Mongolia. Sampling size is calculated according to local population size at a certain percentage. All live births, stillbirths and abortions born from October 2005 to September 2008, whose families lived in Inner Mongolia at least one year, were included. The cases of birth defects were diagnosed by the clinical doctors according to their experiences with further laboratory tests if needed. The inclusion criteria of the cases that had already dead were decided according to death records available at local cites. We calculated prevalence rate and 95% confidence intervals of different groups. Outcome variable was the occurrence of birth defects and associations between risk factors and birth defects