prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in flanders a cross sectional study易感基因型基因毒性效应降低患病率随着年龄的增长在一个随机选择的人口在佛兰德斯横断面研究.pdfVIP

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prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in flanders a cross sectional study易感基因型基因毒性效应降低患病率随着年龄的增长在一个随机选择的人口在佛兰德斯横断面研究.pdf

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prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in flanders a cross sectional study易感基因型基因毒性效应降低患病率随着年龄的增长在一个随机选择的人口在佛兰德斯横断面研究

Ketelslegers et al. Environmental Health 2011, 10:85 /content/10/1/85 RESEARCH Open Access Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study 1 1 1 1 2 Hans B Ketelslegers , Roger WL Godschalk , Ralph WH Gottschalk , Ad M Knaapen , Gudrun Koppen , 2 3 4 5 1 1 Greet Schoeters , Willy F Baeyens , Vera Nelen , Joep PM Geraedts , Joost HM van Delft , Jos CS Kleinjans and Nicolas A van Larebeke6* Abstract Background: We hypothesized that in Flanders (Belgium), the prevalence of at-risk genotypes for genotoxic effects decreases with age due to morbidity and mortality resulting from chronic diseases. Rather than polymorphisms in single genes, the interaction of multiple genetic polymorphisms in low penetrance genes involved in genotoxic effects might be of relevance. Methods: Genotyping was performed on 399 randomly selected adults (aged 50-65) and on 442 randomly selected adolescents. Based on their involvement in processes relevant to genotoxicity, 28 low penetrance polymorphisms affecting the phenotype in 19 genes were selected (xenobiotic metabolism, oxidative stress defense and DNA repair, respectively 13, 6 and 9 polymorphisms). Polymorphisms which, based on available literature, could not clearly be categorized a priori as leading to an ‘increased risk’ or a ‘protective effect’ were excluded. Results: The mean number of risk alleles for all investigated polymorphisms was found to be lower in the ‘elderly’ (17.0 ± 2.9) than the ‘adolescent’ (17.6 ± 3.1) subpop