progestogens to prevent preterm birth in twin pregnancies an individual participant data meta-analysis of randomized trials双胎妊娠孕激素来防止早产个体参与者数据随机试验的荟萃分析.pdfVIP

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progestogens to prevent preterm birth in twin pregnancies an individual participant data meta-analysis of randomized trials双胎妊娠孕激素来防止早产个体参与者数据随机试验的荟萃分析.pdf

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progestogens to prevent preterm birth in twin pregnancies an individual participant data meta-analysis of randomized trials双胎妊娠孕激素来防止早产个体参与者数据随机试验的荟萃分析

Schuit et al. BMC Pregnancy and Childbirth 2012, 12:13 /1471-2393/12/13 STUDY PROTOCOL Open Access Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta- analysis of randomized trials 1* 2 1 3 4 5 Ewoud Schuit , Sarah Stock , Rolf HH Groenwold , Kimberly Maurel , C Andrew Combs , Thomas Garite , 6 7 8 9 10 7 Cathy Y Spong , Elizabeth A Thom , Dwight J Rouse , Steve N Caritis , George R Saade , Julia M Zachary , Jane E Norman2, Line Rode11, Katharina Klein12, Ann Tabor11, Elçin Çetingöz13, John C Morrison14, Everett F Magann15, Christian M Briery16, Vicente Serra17, Alfredo Perales18, Juan Meseguer19, Anwar H Nassar20, 21 1 22 21 Arianne C Lim , Karel GM Moons , Anneke Kwee and Ben Willem J Mol Abstract Background: Preterm birth is the principal factor contributing to adverse outcomes in multiple pregnancies. Randomized controlled trials of progestogens to prevent preterm birth in twin pregnancies have shown no clear benefits. However, individual studies have not had sufficient power to evaluate potential benefits in women at particular high risk of early delivery (for example, women with a previous preterm birth or short cervix) or to determine adverse effects for rare outcomes such as intrauterine death. Methods/design: We propose an individual participant data meta-analysis of high quality randomized, double- blind, placebo-controlled trials of progestogen treatment in women with a twin pregnancy. The primary outcome