quality of life in adults with gilles de la tourette syndrome成年人的生活质量与gilles de la图雷特综合症.pdfVIP

Jalenques et al. BMC Psychiatry 2012, 12:109 /1471-244X/12/109 RESEARCH ARTICLE Open Access Quality of life in adults with Gilles de la Tourette Syndrome 1,7* 1 2 3 1,7 Isabelle Jalenques , Fabienne Galland , Laurent Malet , Dominique Morand , Guillaume Legrand , 4 5 6,7 6,7 Candy Auclair , Andreas Hartmann , Philippe Derost and Franck Durif Abstract Background: Few studies have used standardized QOL instruments to assess the quality of life (QOL) in Gilles de la Tourette Syndrome (GTS) patients. This work investigates the QOL of adult GTS patients and examines the relationships between physical and psychological variables and QOL. Methods: Epidemiological investigation by anonymous national postal survey of QOL of patients of the French Association of Gilles de la Tourette Syndrome (AFGTS) aged 16 years or older. The clinical and QOL measures were collected by four questionnaires: a sociodemographic and GTS-related symptoms questionnaire, the World Health Organization Quality Of Life questionnaire (WHOQOL-26), the Functional Status Questionnaire (FSQ), and a self-rating questionnaire on psychiatric symptoms (SCL-90), all validated in French. We used stepwise regression analysis to explicitly investigate the relationships between physical and psychological variables and QOL domains in GTS. Results: Questionnaires were posted to 303 patients, of whom 167 (55%) completed and returned them. Our results, adjusted for age and gender, show that patients with GTS have a worse QOL than the general healthy population. In particular, the “Depression” psychological variable was a