rapid assessment of hib disease burden in vietnam在越南的快速评估hib疾病负担.pdfVIP

Nyambat et al. BMC Public Health 2011, 11:260 /1471-2458/11/260 RESEARCH ARTICLE Open Access Rapid assessment of Hib disease burden in Vietnam 1* 2 2 2 3 4 Batmunkh Nyambat , Duc Anh Dang , Hien Anh Nguyen , Trinh Quynh Mai , Manju Rani , Mary PE Slack and Paul E Kilgore1 Abstract Background: Several countries have applied the Haemophilus influenzae type b (Hib) rapid assessment tool (RAT) to estimate the burden of Hib disease where resources for hospital- or population-based surveillance are limited. In Vietnam, we used the Hib RAT to estimate the burden of Hib pneumonia and meningitis prior to Hib vaccine introduction. Methods: Laboratory, hospitalization and mortality data were collected for the period January 2004 through December 2005 from five representative hospitals. Based on the WHO Hib RAT protocol, standardized MS Excel spreadsheets were completed to generate meningitis and pneumonia case and death figures. Results: We found 35 to 77 Hib meningitis deaths and 441 to 957 Hib pneumonia deaths among children 5 years of age annually in Vietnam. Overall, the incidence of Hib meningitis was estimated at 18/100,000 (95% confidence interval, CI, 15.1-21.6). The estimated Hib meningitis incidence in children 5 years age was higher in Ho Chi Minh City (22.5/100,000 [95% CI, 18.4-27.5]) compared to Hanoi (9.8/100,000 [95% CI, 6.5-14.8]). The Hib RAT suggests that there are a total of 883 to 1,915 cases of Hib meningitis and 4,414 to 9,574 cases of Hib pneumonia per year in Vietnam. Conclusions: In Hanoi, the estimated incidence of Hib meningitis for children 5 years of age was similar to that described in previous population-based studies of Hib meningitis