resolving structure and mechanical properties at the nanoscale of viruses with frequency modulation atomic force microscopy解决结构和机械性能在纳米尺度上的病毒与调频原子力显微镜.pdfVIP

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2017-09-11 发布于上海
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resolving structure and mechanical properties at the nanoscale of viruses with frequency modulation atomic force microscopy解决结构和机械性能在纳米尺度上的病毒与调频原子力显微镜.pdf

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resolving structure and mechanical properties at the nanoscale of viruses with frequency modulation atomic force microscopy解决结构和机械性能在纳米尺度上的病毒与调频原子力显微镜

Resolving Structure and Mechanical Properties at the Nanoscale of Viruses with Frequency Modulation Atomic Force Microscopy 1. 1,2. 1 1 David Martinez-Martin , Carolina Carrasco , Mercedes Hernando-Perez , Pedro J. de Pablo , Julio 1 3 3 2 4 Gomez-Herrero *, Rebeca Perez , Mauricio G. Mateu , Jose L. Carrascosa , Daniel Kiracofe , John Melcher4, Arvind Raman4 ´ ´ ´ 1 Departamento Fısica de la Materia Condensada, Universidad Autonoma de Madrid, Madrid, Spain, 2 Centro Nacional de Biotecnologıa, CSIC, Madrid, Spain, 3 Centro de ´ Biologıa Molecular ‘‘Severo Ochoa’’ (CSIC), Madrid, Spain, 4 School of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana, United States of America Abstract Structural Biology (SB) techniques are particularly successful in solving virus structures. Taking advantage of the symmetries, a heavy averaging on the data of a large number of specimens, results in an accurate determination of the structure of the sample. However, these techniques do not provide true single molecule information of viruses in physiological conditions. To answer many fundamental questions about the quickly expanding physical virology it is important to develop techniques with the capability to reach nanometer scale resolution on both structure and physical properties of individual molecules in physiological conditions. Atomic force microscopy (AFM) fulfills these