specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用.pdfVIP

下载本文档

1
0
约11.32万字
约 28页
2017-09-12 发布于上海
举报
版权申诉

specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用.pdf

1、本文档共28页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用

Molecules 2012, 17, 10586-10613; doi:10.3390/molecules170910586 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Specific Binding of Anionic Porphyrin and Phthalocyanine to the G-Quadruplex with a Variety of in Vitro and in Vivo Applications Hidenobu Yaku 1,2,3,*, Takashi Murashima 2,3, Daisuke Miyoshi 2,3 and Naoki Sugimoto 2,3 1 Advanced Technology Research Laboratories, Panasonic Corporation, 3-4 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan 2 Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan; E-Mails: murasima@konan-u.ac.jp (T.M.); miyoshi@center.konan-u.ac.jp (D.M.); sugimoto@konan-u.ac.jp (N.S.) 3 Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan * Author to whom correspondence should be addressed; E-Mail: yaku.hidenobu@; Tel.: +81-774-98-2580; Fax: +81-774-98-2585. Received: 31 July 2012; in revised form: 27 August 2012 / Accepted: 29 August 2012 / Published: 5 September 2012 Abstract: The G-quadruplex, a four-stranded DNA structure with stacked guanine tetrads (G-quartets), has recently been attracting attention because of its critical roles in vitro and in vivo. In particular, the G-quadruplex functions as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplex can show peroxidase-like activity with an anionic porphyrin, iron (III) protoporphyrin IX (hemin). Im