specific ige response to different grass pollen allergen components in children undergoing sublingual immunotherapy特定的ige应对不同的草花粉变应原组件在儿童接受舌下免疫治疗.pdfVIP

Marcucci et al. Clinical and Molecular Allergy 2012, 10:7 /content/10/1/7 RESEARCH Open Access Specific IgE response to different grass pollen allergen components in children undergoing sublingual immunotherapy 1* 1 2 3 4 3 Francesco Marcucci , Laura Sensi , Cristoforo Incorvaia , Ilaria Dell’Albani , Giuseppe Di Cara and Franco Frati Abstract Background: Grass pollen is a major cause of respiratory allergy worldwide and contain a number of allergens, some of theme (Phl p 1, Phl p 2, Phl p 5, and Phl 6 from Phleum pratense, and their homologous in other grasses) are known as major allergens. The administration of grass pollen extracts by immunotherapy generally induces an initial rise in specific immunoglobulin E (sIgE) production followed by a progressive decline during the treatment. Some studies reported that immunotherapy is able to induce a de novo sensitisation to allergen component previously unrecognized. Methods: We investigated in 30 children (19 males and 11 females, mean age 11.3 years), 19 treated with sublingual immunotherapy (SLIT) by a 5-grass extract and 11 untreated, the sIgE and sIgG4 response to the different allergen components. Results: Significant increases (p 0.001) were detected for Phl p 1, Phl p 2, Phl p 5, and Phl p 6, while sIgE levels induced in response to Phl p 7 and Phl p 12 were low or absent at baseline and unchanged following SLIT treatment; no new sensitisation was detected. As to IgG4, significant increases were found for Phl p2 and Phl p 5, while the increase for Phl p 12 was not significant. In the control group, no significant increase in sIgE for any single allergen component was found. Conclusions: These findings co