standardized representation, visualization and searchable repository of antiretroviral treatment-change episodes标准化的表示,可视化和可搜索库抗逆转录病毒treatment-change集.pdfVIP

Rhee et al. AIDS Research and Therapy 2012, 9:13 /content/9/1/13 METHODOLOGY Open Access Standardized representation, visualization and searchable repository of antiretroviral treatment-change episodes 1,10* 2 1 2 3 4 5 Soo-Yon Rhee , Jose Luis Blanco , Tommy F Liu , Iñaki Pere , Rolf Kaiser , Maurizio Zazzi , Francesca Incardona , 6 2 7,8 9 1 William Towner , Josep Maria Gatell , Andrea De Luca , W Jeffrey Fessel and Robert W Shafer Abstract Background: To identify the determinants of successful antiretroviral (ARV) therapy, researchers study the virological responses to treatment-change episodes (TCEs) accompanied by baseline plasma HIV-1 RNA levels, CD4+ T lymphocyte counts, and genotypic resistance data. Such studies, however, often differ in their inclusion and virological response criteria making direct comparisons of study results problematic. Moreover, the absence of a standard method for representing the data comprising a TCE makes it difficult to apply uniform criteria in the analysis of published studies of TCEs. Results: To facilitate data sharing for TCE analyses, we developed an XML (Extensible Markup Language) Schema that represents the temporal relationship between plasma HIV-1 RNA levels, CD4 counts and genotypic drug resistance data surrounding an ARV treatment change. To demonstrate the adaptability of the TCE XML Schema to different clinical environments, we collaborate with four clinics to create a public repository of about 1,500 TCEs. Despite the nascent state of this TCE XML Repository, we were able to perform an analysis that generated