stochastic processes are key determinants of short-term evolution in influenza a virus随机过程是短期内甲型流感病毒进化的关键决定因素.pdfVIP

下载本文档

3
0
约6.92万字
约 8页
2017-09-12 发布于上海
举报
版权申诉

stochastic processes are key determinants of short-term evolution in influenza a virus随机过程是短期内甲型流感病毒进化的关键决定因素.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

stochastic processes are key determinants of short-term evolution in influenza a virus随机过程是短期内甲型流感病毒进化的关键决定因素

Stochastic Processes Are Key Determinants of Short-Term Evolution in Influenza A Virus 1 2 3 3 4 4 4 Martha I. Nelson , Lone Simonsen , Cecile Viboud , Mark A. Miller , Jill Taylor , Kirsten St. George , Sara B. Griesemer , Elodie Ghedi5 5 5 1 1,3 6 , Naomi A. Sengamalay , David J. Spiro , Igor Volkov , Bryan T. Grenfell , David J. Lipman , Jeffery K. Taubenberger7, Edward C. Holmes1,3* 1 Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, 2 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Wadsworth Center, New York State Department of Health, Albany, New York, United States of America, 5 The Institute for Genomic Research, Rockville, Maryland, United States of America, 6 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, United States of America, 7 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Understanding the evolutionary dynamics of influenza A virus is central to its surveillance and control. While immune- driven antigenic drift is a key determinant of viral evolution across epidemic seasons, the evolutionary processes shaping influenza virus diversity within seasons are