structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza na inhibition结构和功能分析laninamivir及其辛酸酯前体药物显示组特定的流感na抑制机制.pdfVIP

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition 1. 1,2. 1. 1 1,3 1 4 Christopher J. Vavricka , Qing Li , Yan Wu , Jianxun Qi , Mingyang Wang , Yue Liu , Feng Gao , 1 5 6 5 5 5 1,2,3,7 Jun Liu , Enguang Feng , Jianhua He , Jinfang Wang , Hong Liu , Hualiang Jiang , George F. Gao * 1 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, 2 School of Life Sciences, University of Science and Technology of China, Hefei, China, 3 Graduate University, Chinese Academy of Sciences, Beijing, China, 4 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 5 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, 6 Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China, 7 Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China Abstract The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation of novel NA inhibitors is of great interest. Recently, a highly potent