structural damage in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis traditional views, novel insights gained from tnf blockade, and concepts for the future结构性破坏在风湿性关节炎、银屑病关节炎和强直性脊柱炎的传统观点,新颖的见解从tnf封锁,为未来和概念.pdfVIP

Schett et al. Arthritis Research Therapy 2011, 13(Suppl 1):S4 /content/13/S1/S4 R E V I E W Structural damage in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: traditional views, novel insights gained from TNF blockade, and concepts for the future 1 2 3 1 4 Georg Schett *, Laura C Coates , Zoe R Ash , Stefanie Finzel and Phillip G Conaghan insight into the mechanism of structural changes trig- Abstract gered by chronic joint diseases such as rheumatoid Structural changes of bone and cartilage are a hallmark arthritis (RA), psoriatic arthritis (PsA), and ankylosing of inl ammatory joint diseases such as rheumatoid spondylitis (AS) is essential for developing therapies that arthritis (RA), psoriatic arthritis (PsA), and ankylosing can arrest, prevent, and even reverse bone and cartilage spondylitis (AS). Despite certain similarities – in changes. More specifi c interventions to treat infl amma- particular, inl ammation as the driving force for tion in arthritis, for example monoclonal antibodies and structural changes – the three major inl ammatory soluble receptors, have added considerably to our know- joint diseases show considerably dif erent pathologies. ledge of arthritic structural damage. In particular, the Whereas RA primarily results in bone and cartilage blockade of TNF has shown that eff ective anti-infl am- resorption, PsA combines destructive elements with matory therapy can preserve joint