synthesis and anti-human immunodeficiency virus type 1 activity of (e)-n-phenylstyryl-n-alkylacetamide derivatives合成和反人类免疫缺陷病毒1型(e)活动-n-phenylstyryl-n-alkylacetamide衍生品.pdfVIP

下载本文档

1
0
约4.19万字
约 11页
2017-09-12 发布于上海
举报
版权申诉

synthesis and anti-human immunodeficiency virus type 1 activity of (e)-n-phenylstyryl-n-alkylacetamide derivatives合成和反人类免疫缺陷病毒1型(e)活动-n-phenylstyryl-n-alkylacetamide衍生品.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis and anti-human immunodeficiency virus type 1 activity of (e)-n-phenylstyryl-n-alkylacetamide derivatives合成和反人类免疫缺陷病毒1型(e)活动-n-phenylstyryl-n-alkylacetamide衍生品

Molecules 2009, 14, 3176-3186; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Anti-Human Immunodeficiency Virus Type 1 Activity of (E)-N-Phenylstyryl-N-alkylacetamide Derivatives 1, 2 3 3 3 Pi Cheng *, Ji-Jun Chen , Ning Huang , Rui-Rui Wang , Yong-Tang Zheng and 1 Yi-Zeng Liang 1 School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming 650204, China 3 Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China * Author to whom correspondence should be addressed; E-mail: picheng55@126.com; Tel.: +86-731-8836376. Received: 1 July 2009; in revised form: 30 July 2009 / Accepted: 26 August 2009 / Published: 26 August 2009 Abstract: A series of (E)-N-phenylstyryl-N-alkylacetamides, 5, were synthesized by direct reduction-acetylation of β-arylnitroolefins, followed by N-alkylation. The title compounds were characterized by 1H-NMR, EIMS and IR analysis. All the synthesized compounds were assayed as HIV-1 non-nucleoside reverse transcriptase inhibitors. A SAR study