synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives application in solution peptide synthesis合成2 -(4 6-dimethoxy-1 5-triazin-2-yloxyimino)多肽合成衍生产品应用解决方案.pdfVIP

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synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives application in solution peptide synthesis合成2 -(4 6-dimethoxy-1 5-triazin-2-yloxyimino)多肽合成衍生产品应用解决方案.pdf

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synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives application in solution peptide synthesis合成2 -(4 6-dimethoxy-1 5-triazin-2-yloxyimino)多肽合成衍生产品应用解决方案

Molecules 2010, 15, 9403-9417; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis Tarfah I. Al-Warhi 1,*, Hassan M.A. AL-Hazimi 2, Ayman El-Faham 2,3 and Fernando Albericio 4,5,6 1 Women Students-Medical Studies and Sciences Sections, Chemistry Department, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia 2 Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 3 Chemistry Department, Faculty of Science, Alexandria University, 426 Ibrahimia, 21321 Alexandria, Egypt 4 Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona 08028, Spain 5 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona 08028, Spain 6 Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, Barcelona 08028, Spain * Author to whom correspondence should be addressed; E-Mail: tarfah-w@. Received: 29 November 2010; in revised form: 14 December 2010 / Accepted: 15 December 2010 / Published: 20 December 2010 Abstract: A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but