synthesis of a dual-labeled probe of dimethyl lithospermate b with photochemical and fluorescent propertiesdual-labeled探针的合成二甲基lithospermate b与光化学和荧光性质.pdfVIP

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synthesis of a dual-labeled probe of dimethyl lithospermate b with photochemical and fluorescent propertiesdual-labeled探针的合成二甲基lithospermate b与光化学和荧光性质.pdf

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synthesis of a dual-labeled probe of dimethyl lithospermate b with photochemical and fluorescent propertiesdual-labeled探针的合成二甲基lithospermate b与光化学和荧光性质

Molecules 2011, 16, 9886-9899; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties Eunyoung Lim, Jeremy Ricci and Mankil Jung * Department of Chemistry, Yonsei University, Seoul 120-749, Korea * Author to whom correspondence should be addressed; E-Mail: mjung@yonsei.ac.kr; Tel.: +82-2-2123-2648; Fax: +82-2-364-7050. Received: 1 November 2011; in revised form: 18 November 2011 / Accepted: 22 November 2011 / Published: 28 November 2011 Abstract: Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization. Keywords: dimethyl lithospermate B; target identification; photochemical and fluorescent probe; dual probe 1. Introduction Lithospermic acid B (LAB, 1), a recently isolated component of Salvia miltiorrhiza, is known to have multiple pharmacological activities, including: (1)