原创力文档synthesis of biotin linkers with the activated triple bond donor [p-(n-propynoylamino)toluic acid] (pata) for efficient biotinylation of peptides and oligonucleotides合成生物素和激活链接器三键捐赠(p -(n-propynoylamino)甲苯酸)(pata)高效生物素酰化肽与寡核苷酸.pdfVIP
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synthesis of biotin linkers with the activated triple bond donor [p-(n-propynoylamino)toluic acid] (pata) for efficient biotinylation of peptides and oligonucleotides合成生物素和激活链接器三键捐赠(p -(n-propynoylamino)甲苯酸)(pata)高效生物素酰化肽与寡核苷酸
Molecules 2012, 17, 14174-14185; doi:10.3390/molecules171214174
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
Synthesis of Biotin Linkers with the Activated Triple Bond
Donor [p -(N-propynoylamino)toluic Acid] (PATA) for Efficient
Biotinylation of Peptides and Oligonucleotides
Martina Jezowska 1, Joanna Romanowska 1,2, Burcu Bestas 3, Ulf Tedebark 4 and
Malgorzata Honcharenko 1,*
1 Department of Biosciences and Nutrition, Karolinska Institutet, Novum, SE-14183 Huddinge,
Sweden; E-Mail: Martina.Jezowska@ki.se (M.J.)
2 Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14,
61-704 Poznañ, Poland; E-Mail: joarom@ibch.poznan.pl (J.R.)
3 Clinical Research Center, Karolinska Institutet, Karolinska University Hospital Huddinge, Novum,
SE-14186 Huddinge, Sweden; E-Mail: burcu.bestas@ki.se
4 GE Healthcare Bio-Sciences AB, Björkgatan 30, SE-75184 Uppsala, Sweden;
E-Mail: Ulf.Tedebark@
* Author to whom correspondence should be addressed; E-Mail: Malgorzata.Honcharenko@ki.se;
Tel.: +46-8-524-81019; Fax: +46-8-524-81034.
Received: 1 November 2012; in revised form: 19 November 2012 / Accepted: 23 November 2012 /
Published: 30 November 2012
Abstract: Biotin is an important molecule for modern biological studies including, e.g.,
cellular transport. Its exclusive affinity to fluorescent streptavidin/avidin proteins allows
ready and specific detection. As a consequence methods for the attachment of biotin to
various biological targets are of high i
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