synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential hiv-1 nnrtis(合成新颖的衍生品4-amino-3)- 2-furyl 5-mercapto-1,2,4-triazole作为潜在的hiv - 1 nnrtis.pdfVIP

下载本文档

1
0
约5.76万字
约 14页
2017-09-12 发布于上海
举报
版权申诉

synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential hiv-1 nnrtis(合成新颖的衍生品4-amino-3)- 2-furyl 5-mercapto-1,2,4-triazole作为潜在的hiv - 1 nnrtis.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential hiv-1 nnrtis(合成新颖的衍生品4-amino-3)- 2-furyl 5-mercapto-1,2,4-triazole作为潜在的hiv - 1 nnrtis

Molecules 2007, 12, 2003-2016 molecules ISSN 1420-3049 © 2007 by MDPI /molecules Full Paper Synthesis of Novel Derivatives of 4-Amino-3-(2-Furyl)-5-Mercapto-1,2,4-Triazole as Potential HIV-1 NNRTIs Jingde Wu 1, Xinyong Liu 1,*, Xianchao Cheng 1, Yuan Cao 1, Defeng Wang 1, Zhong Li 1, 1 2 2 2 Wenfang Xu , Christophe Pannecouque , Myriam Witvrouw and Erik De Clercq 1 Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No.44, Wenhuaxi Road, Jinan, 250012, P.R. China 2 Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium; E- mail: erik.declercq@rega.kuleuven.be (Erik De Clercq) * Author to whom correspondence should be addressed; E-mail: xinyongl@; Tel: (+86)-531 Fax: (+86)-531 Received: 21 July 2007; in revised form: 17 August 2007 / Accepted: 20 August 2007 / Published: 21 August 2007 Abstract: A series of 5-alkylthio (2a-d), 4-arylideneamino (3a-d) and 4-arylideneamino- 5-alkylthio derivatives (4a-f) of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole (1) were synthesized by alkylation of the parent compound with alkyl halides and condensation with aldehydes, respectively. Sulfanyl dimers 5a-d and 4-iminomethyl dimer 6 were correspondingly prepared by reaction with alkane dibromides and 1,4-diformylbenzene. Mannich base 7 was also synthesized by aminomethylation of the 3-sulfanyltriazole 1 at the N