原创力文档targeted disruption of ing2 results in defective spermatogenesis and development of soft-tissue sarcomas针对中断ing2导致有缺陷的精子发生和发展的软组织肉瘤.pdfVIP
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targeted disruption of ing2 results in defective spermatogenesis and development of soft-tissue sarcomas针对中断ing2导致有缺陷的精子发生和发展的软组织肉瘤
Targeted Disruption of Ing2 Results in Defective
Spermatogenesis and Development of Soft-Tissue
Sarcomas
1,2 1,2 1 1 3
Motonobu Saito , Kensuke Kumamoto , Ana I. Robles , Izumi Horikawa , Bungo Furusato , Shu
1 1 1 1 4 4
Okamura , Akiteru Goto , Taro Yamashita , Makoto Nagashima , Tin-Lap Lee , Vanessa J. Baxendale ,
4 2 5 3 1
Owen M. Rennert , Seiichi Takenoshita , Jun Yokota , Isabell A. Sesterhenn , Glenwood E. Trivers , S.
1 1
Perwez Hussain , Curtis C. Harris *
1 Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America,
2 Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan, 3 Department of Genitourinary Pathology, Armed Forces
Institute of Pathology, Washington, D.C., United States of America, 4 Laboratory of Clinical and Developmental Genomics, Program in Reproductive and Adult
Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, 5 Biology Division,
National Cancer Center Research Institute, Tokyo, Japan
Abstract
ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of
putative tumor suppressors. As part of mSin3A-HDAC corepressor complexes, ING2 binds to tri-methylated lysin
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