原创力文档targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease should we keep our hats on针对类风湿性关节炎和哮喘组蛋白脱乙酰酶活动的原型炎性疾病我们应该保持我们的帽子.pdfVIP
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targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease should we keep our hats on针对类风湿性关节炎和哮喘组蛋白脱乙酰酶活动的原型炎性疾病我们应该保持我们的帽子
Available online /content/10/5/226
Review
Targeting histone deacetylase activity in rheumatoid arthritis and
asthma as prototypes of inflammatory disease: should we keep
our HATs on?
Aleksander M Grabiec, Paul P Tak and Kris A Reedquist
Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam,
The Netherlands
Corresponding author: Kris A Reedquist, k.a.reedquist@amc.uva.nl
Published: 17 October 2008 Arthritis Research Therapy 2008, 10:226 (doi:10.1186/ar2489)
This article is online at /content/10/5/226
© 2008 BioMed Central Ltd
Abstract distinct components of this network, such as TNFα, IL-1, IL-6
Cellular activation, proliferation and survival in chronic inflammatory and receptor activator of NFκB ligand, contribute to
diseases is regulated not only by engagement of signal trans- inflammation and joint destruction in RA have been translated
duction pathways that modulate transcription factors required for into innovative and increasingly successful treatment of
these processes, but also by epigenetic regulation of transcription patients in the clinic [1]. Many of the extracellular stimuli
factor access to gene promoter regions. Histone acetyl trans- driving pathology in RA do so through the activation of con-
ferases coordinate the recruitment and activation of transcription
served intracellular signaling proteins and pathways, inclu-
factors with conformational changes
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