synthesis and toxicity evaluation of some n4-aryl substituted 5-trifluoromethoxyisatin-3-thiosemicarbazones合成和毒性评价一些n4-aryl 5-trifluoromethoxyisatin-3-thiosemicarbazones代替.pdfVIP

下载本文档

1
0
约6.68万字
约 14页
2017-09-12 发布于上海
举报
版权申诉

synthesis and toxicity evaluation of some n4-aryl substituted 5-trifluoromethoxyisatin-3-thiosemicarbazones合成和毒性评价一些n4-aryl 5-trifluoromethoxyisatin-3-thiosemicarbazones代替.pdf

1、本文档共14页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

synthesis and toxicity evaluation of some n4-aryl substituted 5-trifluoromethoxyisatin-3-thiosemicarbazones合成和毒性评价一些n4-aryl 5-trifluoromethoxyisatin-3-thiosemicarbazones代替

Molecules 2011, 16, 6408-6421; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article 4 Synthesis and Toxicity Evaluation of Some N -Aryl Substituted 5-Trifluoromethoxyisatin-3-thiosemicarbazones Humayun Pervez 1,*, Naveeda Saira 1, Mohammad Saeed Iqbal 2, Muhammad Yaqub 1 and 3 Khalid Mohammed Khan 1 Department of Chemistry, Bahauddin Zakariya University, Multan-60800, Pakistan 2 Department of Chemistry, FC College, Lahore-54600, Pakistan 3 H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan * Author to whom correspondence should be addressed; E-Mail: pdhpervez@; Tel.: +92-61-9210083; Fax: +92-61-9210138. Received: 16 June 2011; in revised form: 13 July 2011 / Accepted: 22 July 2011 / Published: 29 July 2011 4 Abstract: A series of twenty one N -aryl substituted 5-trifluoromethoxyisatin-3- thiosemicarbazones 3a-3u was synthesized by the reaction of trifluoromethoxyisatin 1 with different arylthiosemicarbazides 2 in aqueous ethanol (50%), containing a few drops of acetic acid. Their structures were established on the basis of analytical (CHN) and spectral (IR, 1H-NMR, EIMS) data. All the synthesized compounds were evaluated for their toxicity potential by a brine shrimp