原创力文档t-cell responses to the dblα-tag, a short semi-conserved region of the plasmodium falciparum membrane erythrocyte protein 1dblα-tag t细胞反应,短semi-conserved地区恶性疟原虫膜红细胞蛋白质1.pdfVIP
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t-cell responses to the dblα-tag, a short semi-conserved region of the plasmodium falciparum membrane erythrocyte protein 1dblα-tag t细胞反应,短semi-conserved地区恶性疟原虫膜红细胞蛋白质1
T-Cell Responses to the DBLa-Tag, a Short Semi-
Conserved Region of the Plasmodium falciparum
Membrane Erythrocyte Protein 1
1,2 1 1¤ 1 1 1,3
Evelyn N. Gitau , James Tuju , Liz Stevenson , Eva Kimani , Henry Karanja , Kevin Marsh , Peter C.
Bull1,3, Britta C. Urban1,2*
1 KEMRI-Wellcome Trust Collaborative Programme, Centre for Geographic Medicine Coast, Kilifi, Kenya, 2 Liverpool School of Tropical Medicine, Liverpool, United
Kingdom, 3 Centre for Tropical Medicine, Nuffield Department of Internal Medicine, Oxford University, Oxford, United Kingdom
Abstract
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen expressed on mature
forms of infected erythrocytes. It is considered an important target of naturally acquired immunity. Despite its extreme
sequence heterogeneity, variants of PfEMP1 can be stratified into distinct groups. Group A PfEMP1 have been
independently associated with low host immunity and severe disease in several studies and are now of potential interest as
vaccine candidates. Although antigen-specific antibodies are considered the main effector mechanism in immunity to
malaria, the induction of efficient and long-lasting antibody responses requires CD4+ T-cell help. To date, very little is known
about CD4+ T-cell responses to PfEMP1 expressed on clinical isolates. The DBLa-tag is a small region from the DBLa-domain
of PfEMP1 that can be amplified with universal primers and is accessible in clinical parasite isolates. We identified the
dominant expressed PfEMP1 in 41 individual clinical parasite isolates and expr
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