the aaa-atpase vps4 regulates extracellular secretion and lysosomal targeting of α-synuclein的aaa-atpase vps4α-synuclein调节胞外分泌物和溶酶体的目标.pdfVIP

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of a-Synuclein 1 1 1 1 1 Takafumi Hasegawa *, Masatoshi Konno , Toru Baba , Naoto Sugeno , Akio Kikuchi , Michiko 1 1 2 2 3 3 Kobayashi , Emiko Miura , Nobuyuki Tanaka , Keiichi Tamai , Katsutoshi Furukawa , Hiroyuki Arai , 4 4 1 1,5 1 Fumiaki Mori , Koichi Wakabayashi , Masashi Aoki , Yasuto Itoyama , Atsushi Takeda 1 Division of Neurology, Department of Neuroscience Sensory Organs, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, 2 Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori, Miyagi, Japan, 3 Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan, 4 Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan, 5 National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan Abstract Many neurodegenerative diseases share a common pathological feature: the deposition of amyloid-like fibrils composed of misfolded proteins. Emerging evidence suggests that these proteins may spread from cell-to-cell and encourage the propagation of neurodegeneration in a prion-like manner. Here, we demonstrated that a-synuclein (aSYN), a principal culprit for Lewy pathology in Parkins