原创力文档the association between ogg1 ser326cys polymorphism and lung cancer susceptibility a meta-analysis of 27 studies之间的关联ogg1 ser326cys多态性与肺癌易感性27个研究的荟萃分析.pdfVIP
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the association between ogg1 ser326cys polymorphism and lung cancer susceptibility a meta-analysis of 27 studies之间的关联ogg1 ser326cys多态性与肺癌易感性27个研究的荟萃分析
The Association between OGG1 Ser326Cys
Polymorphism and Lung Cancer Susceptibility: A Meta-
Analysis of 27 Studies
1. 2,3. 1. 4 1 4 1
Wei-Xun Duan , Rui-Xi Hua , Wei Yi , Li-Jun Shen , Zhen-Xiao Jin , Yu-Hong Zhao , Ding-Hua Yi ,
1 1
Wen-Sheng Chen *, Shi-Qiang Yu *
1 Department of Cardiothoracic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China, 2 Department of Medical Oncology, Fudan University
Shanghai Cancer Center, Shanghai, China, 3 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 4 Zhejiang Provincial Key Laboratory
of Medical Genetics, Wenzhou Medical College, Wenzhou, China
Abstract
Background: Numerous studies have investigated association of OGG1 Ser326Cys polymorphism with lung cancer
susceptibility; however, the findings are inconsistent. Therefore, we performed a meta-analysis based on 27 publications
encompass 9663 cases and 11348 controls to comprehensively evaluate such associations.
Methods: We searched publications from MEDLINE and EMBASE which were assessing the associations between OGG1
Ser326Cys polymorphism and lung cancer risk. We calculated pooled odds ratio (OR) and 95% confidence interval (CI) by
using either fixed-effects or random-effects model. We used genotype based mRNA expression data from HapMap for SNP
rs1052133 in normal cell lines among 270 subjects with four different ethnicities.
Results: The results showed that individuals carrying the Cys/Cys genotype did not have significantly increased risk for lung
cancer (OR = 1.15, 95% CI = 0.98–1.36) when compared with the Ser/Ser genotype; similarly, no signif
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