原创力文档the baboon (papio spp.) as a model of human ebola virus infection狒狒(papio spp。)作为人类埃博拉病毒感染模型.pdfVIP
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the baboon (papio spp.) as a model of human ebola virus infection狒狒(papio spp。)作为人类埃博拉病毒感染模型
Viruses 2012, 4, 2400-2416; doi:10.3390/v4 102400
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
The Baboon (Papio spp.) as a Model of Human Ebola
Virus Infection
Donna L. Perry 1,*, Laura Bollinger 1 and Gary L.White 2
1 Integrated Research Facility, Division of Clinical Research, NIAID, NIH, Frederick, MD, USA;
E-Mail: bollingerl@
2 Department of Pathology, University of Oklahoma Baboon Research Resource, University of
Oklahoma, Ft. Reno Science Park, OK, USA; E-Mail: gary-white@
* Author to whom correspondence should be addressed; E-Mail: perrydl@;
Tel.: +1-301-631-7249; Fax: +1-301-619-5029.
Received: 8 October 2012; in revised form: 17 October 2012 / Accepted: 17 October 2012 /
Published: 23 October 2012
Abstract: Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96%
genetic homology with humans. Despite these characteristics, baboons have rarely been
utilized as experimental models of human EBOV infection to evaluate the efficacy of
prophylactics and therapeutics in the United States. This review will summarize what is
known about the pathogenesis of EBOV infection in baboons compared to EBOV infection
in humans and other Old World nonhuman primates. In addition, we will discuss how
closely the baboon model recapitulates human EBOV infection. We will also review some
of the housing requirements and behavioral attributes of baboons compared to other Old
World nonhuman primates.
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