the base excision repair pathway is required for efficient lentivirus integration基本切除修复途径需要高效的慢病毒整合.pdfVIP

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the base excision repair pathway is required for efficient lentivirus integration基本切除修复途径需要高效的慢病毒整合.pdf

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the base excision repair pathway is required for efficient lentivirus integration基本切除修复途径需要高效的慢病毒整合

The Base Excision Repair Pathway Is Required for Efficient Lentivirus Integration 1 3 7 7 4 Kristine E. Yoder *, Amy Espeseth , Xiao-hong Wang , Qingming Fang , Maria Teresa Russo , R. Stephen 5 3 6,7,8 1,2 Lloyd , Daria Hazuda , Robert W. Sobol , Richard Fishel * 1 Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America, 2 Physics Department, The Ohio State University, Columbus, Ohio, United States of America, 3 Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America, 4 Department of Environment and Primary Prevention, Istituto ` Superiore di Sanita, Rome, Italy, 5 Center for Research on Occupational and Environmental Toxicology, Department of Molecular and Medical Genetics, Oregon Health Science University, Portland, Oregon, United States of America, 6 Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 7 University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America, 8 Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America Abstract An siRNA screen has identified several proteins throughout the base excision repair (BER) pathway of oxidative DNA damage as important for efficient HIV infection. The proteins identified included early