the binding affinity and molecular basis of the structure-binding relationship between urinary tamm-horsfall glycoprotein and tumor necrosis factor-α的亲和力、分子基础structure-binding尿tamm-horsfall糖蛋白和肿瘤坏死factor-α之间的关系.pdfVIP

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the binding affinity and molecular basis of the structure-binding relationship between urinary tamm-horsfall glycoprotein and tumor necrosis factor-α的亲和力、分子基础structure-binding尿tamm-horsfall糖蛋白和肿瘤坏死factor-α之间的关系.pdf

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the binding affinity and molecular basis of the structure-binding relationship between urinary tamm-horsfall glycoprotein and tumor necrosis factor-α的亲和力、分子基础structure-binding尿tamm-horsfall糖蛋白和肿瘤坏死factor-α之间的关系

Molecules 2012, 17, 11978-11989; doi:10.3390/molecules171011978 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Binding Affinity and Molecular Basis of the Structure-Binding Relationship between Urinary Tamm-Horsfall Glycoprotein and Tumor Necrosis Factor-α Cheng-Han Wu 1,†, Ko-Jen Li 2,†, Sue-Cien Siao 3, Yu-Hsuan Chen 3, Tsai-Hung Wu 4, Chang-Youh Tsai 5 and Chia-Li Yu 3,* 1 Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, No.7 Chung-Shan South Road, Taipei 100, Taiwan 2 Institute of Clinical medicine, National Yang-Ming University College of Medicine, No.155 Li-Nong Street, Shih-Pai, Taipei 11217, Taiwan 3 Institute of Molecular Medicine, National Taiwan University College of Medicine, No.7 Chung-Shan South Road, Taipei 100, Taiwan 4 Section of Nephrology, Taipei Veterans General Hospital, No.201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan 5 Section of Allergy, Immunology and Rheumatology, Taipei Veterans General Hospital, No.201 Section 2, Shih-Pai Road, Taipei 11217, Taiwan † These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: chialiyu@.tw; Tel.: +886-2-2312-3456 (ext. 65011); Fax: +886-2-2395-7801. Received: 13 July 2012; in revised form: 26 September 2012 / Accepted: 8 October 2012 / Published: 11 October 2012 Abstract: In a previous study we noted significant THP binding to TNF-α, but did not explore the molecular basis of the structure-binding relat