the critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin精氨酸残基的至关重要的作用在人类单克隆抗体的结合心磷脂.pdfVIP
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the critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin精氨酸残基的至关重要的作用在人类单克隆抗体的结合心磷脂
Available online /content/7/1/R47
Vol 7 No 1 Open Access
Research article
The critical role of arginine residues in the binding of human
monoclonal antibodies to cardiolipin
1,2 1,2 2 3 3
Ian Giles , Nancy Lambrianides , David Latchman , Pojen Chen , Reginald Chukwuocha ,
David Isenberg1 and Anisur Rahman1,2
1Centre for Rheumatology, Department of Medicine, University College London, UK
2Medical Molecular Biology Unit, Institute of Child Health, University College London, UK
3Department of Medicine, Division of Rheumatology, University of California, Los Angeles, USA
Corresponding author: Ian Giles, i.giles@ich.ucl.ac.uk
Received: 28 May 2004 Revisions requested: 10 Aug 2004 Revisions received: 31 Aug 2004 Accepted: 23 Sep 2004 Published: 16 Nov 2004
Arthritis Res Ther 2005, 7:R47-R56 (DOI 10.1186/ar1449)
/content/7/1/R47
© 2004 Giles et al., licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/
2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited.
Abstract
Previously we reported that the variable heavy chain region (V ) of the 32 expressed heavy chain/light chain combinations to
H
of a human beta2 glycoprotein I-dependent monoclonal bind CL was determined by ELISA.
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