the effect of monthly sulfadoxine-pyrimethamine, alone or with azithromycin, on pcr-diagnosed malaria at delivery a randomized controlled trial每月磺胺多辛-乙胺嘧啶的影响,单独或与阿奇霉素,pcr-diagnosed疟疾在交付一个随机对照试验.pdfVIP
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the effect of monthly sulfadoxine-pyrimethamine, alone or with azithromycin, on pcr-diagnosed malaria at delivery a randomized controlled trial每月磺胺多辛-乙胺嘧啶的影响,单独或与阿奇霉素,pcr-diagnosed疟疾在交付一个随机对照试验
The Effect of Monthly Sulfadoxine-Pyrimethamine, Alone
or with Azithromycin, on PCR-Diagnosed Malaria at
Delivery: A Randomized Controlled Trial
1 1 2 3,4 1
Mari Luntamo *, Anne-Maria Rantala , Steven R. Meshnick , Yin Bun Cheung , Teija Kulmala ,
Kenneth Maleta5, Per Ashorn1,6
1 Department of International Health, University of Tampere Medical School, Tampere, Finland, 2 Department of Epidemiology, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, North Carolina, United States of America, 3 Singapore Clinical Research Institute, Singapore, Singapore, 4 Duke-NUS Graduate
Medical School Singapore, Singapore, 5 College of Medicine, University of Malawi, Blantyre, Malawi, 6 Department of Pediatrics, Tampere University Hospital, Tampere,
Finland
Abstract
Background: New regimens for intermittent preventive treatment in pregnancy (IPTp) against malaria are needed as the
effectiveness of the standard two-dose sulfadoxine-pyrimethamine (SP) regimen is under threat. Previous trials have shown
that IPTp with monthly SP benefits HIV-positive primi- and secundigravidae, but there is no conclusive evidence of the
possible benefits of this regimen to HIV-negative women, or to a population comprising of both HIV-positive and –negative
women of different gravidities.
Methods: This study analyzed 484 samples collected at delivery as part of a randomized, partially placebo controlled clinical
trial, conducted in rural Malawi between 2003 and 2007. The study included pregnant women regardless of their gravidity
or HIV-infection status. The participants received SP twice (controls), monthly SP, or monthly SP and two doses of
azithromyci
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