原创力文档the flavonoid luteolin inhibits fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice类黄酮的毛地黄黄酮抑制fcγ-dependent粒细胞呼吸爆发,但不是皮肤起泡在成年老鼠类天疱疮的新模式.pdfVIP
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the flavonoid luteolin inhibits fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice类黄酮的毛地黄黄酮抑制fcγ-dependent粒细胞呼吸爆发,但不是皮肤起泡在成年老鼠类天疱疮的新模式
The Flavonoid Luteolin Inhibits Fcc-Dependent
Respiratory Burst in Granulocytes, but Not Skin Blistering
in a New Model of Pemphigoid in Adult Mice
1,2,4 2 2 ¨ 3 2,5,6
Eva Oswald , Alina Sesarman , Claus-Werner Franzke , Ute Wolfle , Leena Bruckner-Tuderman ,
1 1 2,5
Thilo Jakob , Stefan F. Martin , Cassian Sitaru *
1 Allergy Research Group, Department of Dermatology, University Freiburg Medical Center, Freiburg, Germany, 2 Molecular Dermatology, Department of Dermatology,
University Freiburg Medical Center, Freiburg, Germany, 3 Competence Centre Skintegral, Department of Dermatology, University Freiburg Medical Center, Freiburg,
Germany, 4 Faculty of Biology, University of Freiburg, Freiburg, Germany, 5 BIOSS Centre for Biological Signalling Studies, Freiburg, Germany, 6 Freiburg Institute for
Advanced Studies, Freiburg, Germany
Abstract
Bullous pemphigoid is an autoimmune blistering skin disease associated with autoantibodies against the dermal-epidermal
junction. Passive transfer of antibodies against BP180/collagen (C) XVII, a major hemidesmosomal pemphigoid antigen, into
neonatal mice results in dermal-epidermal separation upon applying gentle pressure to their skin, but not in spontaneous
skin blistering. In addition, this neonatal mouse model precludes treatment and observation of diseased animals beyond 2–
3 days. Therefore, in the present study we have developed a new disease model in mice reproducing the spontaneous
blistering and the chronic course characteristic of the human condition. Adult mice were pre-immunized with rabbit IgG
followed by
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