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the glucocorticoid receptor a revisited target for toxins糖皮质激素受体的重新审视目标毒素
Toxins 2010, 2, 1357-1380; doi:10.3390/toxins2061357
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Review
The Glucocorticoid Receptor: A Revisited Target for Toxins
Jeanette I. Webster Marketon 1,2,* and Esther M. Sternberg 3
1 Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care Sleep Medicine,
201 DHLRI, 473 W. 12th Avenue, Columbus, OH 43210, USA
2 Institute for Behavioral Medicine Research, The Ohio State University Medical Center, 460
Medical Center Drive, Columbus, OH 43210, USA
3 Department of Health and Human Services, Section on Neuroendocrine Immunology and Behavior,
National Institute of Mental Health, National Institutes of Health, 5625 Fishers Lane, Rm. 4N13
(MSC 9401), Bethesda, MD 20892-9401, USA; E-Mail: sternbee@
* Author to whom correspondence should be addressed; E-Mail: jeanette.marketon@ ;
Tel.: +1-614-293-3496; Fax: +1-614-366-2074.
Received: 15 May 2010, in revised form: 28 May 2010 / Accepted: 7 June 2010 /
Published: 9 June 2010
Abstract: The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid
responses are critical for survival from a number of bacterial, viral and toxic insults,
demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality
rates. Replacement with synthetic glucocorticoids reverses these effects by providing
protection against lethal effects. Glucocorticoid resistance/insensitivity is a common
problem in the treatment of many disea
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